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Full-length Membrane Protein Products
Transmembrane proteins are a type of protein that are embedded in the phospholipid bilayer of the cell membrane to achieve intracellular and extracellular crossing. The interaction in the transmembrane region is an important pathway connecting the extracellular environment and the intracellular environment, in order to perform various activation and response reactions to achieve signal transduction, regulate morphological and functional changes inside and outside the cell.
Many human diseases may be related to abnormal transmembrane protein function, and the multifunctionality of transmembrane proteins makes them ideal drug targets.
Due to the hydrophobic and lipophilic transmembrane domain of transmembrane proteins, it is necessary to rely on the special environment of the phospholipid bilayer of the cell membrane to maintain the correct structure and biological activity. At the same time, the more times they cross the membrane, the more hydrophobic and lipophilic transmembrane regions they have, and the lower their expression level in host cells, the greater the difficulty of preparation.
Regarding the difficulties in preparing multiple transmembrane proteins, non cellular protein expression can solve the corresponding difficulties and express the required membrane proteins; We offer a complete range of full-length and structurally sound transmembrane protein products, including four transmembrane proteins CD20 and Claudin18.2, six transmembrane proteins STEAP1, seven transmembrane proteins GPRC5D and CCR8, and twelve transmembrane proteins SLC7A11.
We can also provide cell-free protein expression membrane protein purification services to assist in drug development and scientific research! Welcome to inquire~
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