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Automated High-Throughput Protein Screening Workstation
A new paradigm of protein R&D --- PLD CFPS + XR fully automatic liquid handling workstation = high-throughput, automated protein synthesis and screening workstation
Workstation Overview
PLD Technology has redefined the efficiency and precision of protein synthesis and screening by leveraging its proprietary Cell-Free Protein Synthesis (CFPS) platform, combined with a fully automated liquid handling workstation created by XR Technology. Traditional cell-dependent expression systems are constrained by host cell growth cycles, toxicity tolerance, and operational complexity, making it difficult to meet the demand for high-throughput automation. The joint high-throughput automated workstation from PLD Technology and XR Technology breaks through these limitations with the following innovations:
CFPS System
Extracts transcription and translation machinery from cell lysates to synthesize proteins directly in vitro without cell culture, eliminating the need for cell culture and bypassing host limitations. This system is ideal for high-throughput applications.
Fully Automated Workflow
Completing PCR and high-throughput CFPS within as short as four hours, the entire process is automatically performed via the liquid handling workstation, minimizing human error.
High-throughput Compatibility
Supports 96-well plate parallel processing, enabling daily handling of thousands of samples. Suitable for enzyme-directed evolution, antibody screening, AI-driven protein design and validation, and more.
Supporting automated equipment
China Analysis
SC9300 384SE
Number of board positions: 8
Number of channels: 8+1 channels
Magnetic separation frame: None
Scalability: None
China Analysis
SC9320
Number of board positions: 8
Number of channels: 8+1 channels
Magnetic separation frame: available
Scalability: Supported
Mystic Blade
XR-FLUENT-A12
Number of board positions: 8
Number of channels: 8+1 channels
Magnetic separation frame: available
Scalability: Supported
Workstation Advantages
Say goodbye to tedious cell culture and rapidly produce high-purity proteins.
Quick: It takes only a few hours to generate a functional antibody molecule from linear DNA, representing more than a tenfold increase in R&D efficiency compared with conventional cell-based systems (which require several weeks to months).
Template flexibility: Supports linearized DNA fragments as templates
No antibody type restrictions: Compatible with various formats, including VHH, scFv, Fab, and full-length antibodies, and supports disulfide bond formation.
High-throughput automation: Daily screening of 3,000 antibodies, with automated synthesis and no manual intervention, enabling a seamless end-to-end workflow from gene to protein and significantly reducing labor costs.
Open system: Reaction conditions (such as pH and temperature) can be freely adjusted.
Direct detection without purificationThe reaction supernatant can be directly used for ELISA assays, eliminating the time-consuming purification step and accelerating functional validation and screening.
Case Showcase
Case Study 1: High-throughput CFPS and Screening based on Mutant Library—phi29 DNA Polymerase
By establishing a CFPS high-throughput screening and validation of mutant enzymes, PLD completed the expression and assay of 96 phi29 DNA polymerase mutants in 3 days, identifying high-efficiency variants. This approach drastically reduced screening time and labor costs, and greatly improved the R&D efficiency.
Case Study 2: High-throughput screening model for targeted mutant GFP
Used on the high-throughput automation workstation, PLD's CFPS platform quickly achieved mutant protein synthesis and screening involving each of the five sites in the active center of the green fluorescent protein GFP.
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Contact Information
Service Hotline: +86-512-67900128
Customer Service: order@sz-pld.tech
Business Cooperation: bd@sz-pld.tech
Address: Room 302, Building 1, Weili Medical Science and Technology Park, No. 69 Jiepu Road, Suzhou Industrial Park
