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Recently, the team led by Chen Shi and Wang Lianrong published in Molecular Cell a groundbreaking study titled “The Ppl protein senses 3′-hydroxyl DNA overhangs and NTP depletion to halt phage infection” (DOI: 10.1016/j.molcel.2025.11.011), with an impact factor of 16.6. The research unveils a novel mechanism by which bacteria rely on a single protein to simultaneously monitor two critical signals—3′‑hydroxyl DNA overhangs and NTP depletion—and rapidly activate defense responses during bacteriophage infection, thereby providing a new theoretical foundation for understanding bacterial strategies against phage attacks.
2025/12/17
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