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    Core protein solutions that drive interdisciplinary research and industrial breakthroughs

    An “Accelerator” for Directed Enzyme Evolution: A High-Throughput Screening Strategy Based on CFPS (Part I)

    An “Accelerator” for Directed Enzyme Evolution: A High-Throughput Screening Strategy Based on CFPS (Part I)

    Enzymes are crucial functional proteins in nature, and their catalytic activity plays a pivotal role in fields such as gene editing and stem cell technologies, the production of targeted therapeutics, the food industry, the textile industry, medical diagnostics, and drug synthesis. However, due to limitations in thermal stability, pH tolerance, solvent compatibility, substrate specificity, and catalytic efficiency, natural enzymes are often not the optimal choice for industrial applications. Directed evolution is a widely used approach to enhance enzyme catalytic performance and thermal stability.

    2024/10/11

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    A More Comprehensive New Approach to Antibody Expression—Cell-Free Protein Expression (Surprise at the End)

    A More Comprehensive New Approach to Antibody Expression—Cell-Free Protein Expression (Surprise at the End)

    Global research on antibody therapeutics is thriving, and China’s antibody drug development is equally vigorous. At present, recombinant antibody production primarily relies on mammalian cell expression systems such as CHO cells, while Escherichia coli is typically used only for expressing antibody fragments. Although the CHO cell system can produce full-length antibodies, it still faces challenges including difficult cell culture, cumbersome procedures, lengthy expression cycles, and high costs.

    2024/09/14

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    CFPS is invincible; the challenge of membrane proteins has been effortlessly overcome.

    CFPS is invincible; the challenge of membrane proteins has been effortlessly overcome.

    Membrane proteins play crucial roles in numerous cellular processes, including transport, signal transduction, and proliferation and differentiation, and they constitute important drug targets. However, due to low expression levels, conformational instability, and difficulties in isolation and purification, many studies are hampered by the challenge of expressing membrane proteins, thereby stalling progress.

    2024/09/09

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    Sutro’s new ADC development approach: nnAA insertion based on CFPS

    Sutro’s new ADC development approach: nnAA insertion based on CFPS

    Recently, Perotin Bio announced that it is offering protein expression services featuring site-specific incorporation of non-canonical amino acids, leveraging its proprietary cell-free protein synthesis (CFPS) platform, thereby attracting widespread attention within the industry.

    2024/08/27

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    CFPS technology efficiently incorporates non‑natural amino acids, opening up new frontiers in scientific research!

    CFPS technology efficiently incorporates non‑natural amino acids, opening up new frontiers in scientific research!

    Non‑natural amino acids (ncAAs) are a class of specialized amino acids that are not constrained by the genetic code. They possess unique spatial conformations and chemical properties, and by precisely incorporating them into proteins, we can endow these proteins with novel chemical, physical, and biological activities. In recent years, driven by rapid advances in biotechnology and medicine, non‑natural amino acids have demonstrated tremendous application potential in areas such as biological research, drug development, and medical diagnostics. Cell‑free protein synthesis (CFPS), as an innovative protein expression platform, has greatly facilitated the production of engineered proteins; by integrating ncAAs, it has enabled the development of versatile strategies that can significantly enhance the efficiency of ncAA incorporation.

    2024/08/20

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    Cell-free protein expression: Making membrane protein expression no longer a challenge.

    Cell-free protein expression: Making membrane protein expression no longer a challenge.

    Membrane proteins, as complex functional proteins, play crucial roles in substance transport, signal transduction, energy conversion, and cell proliferation and differentiation. Given their diverse cellular functions, membrane proteins have long been a focal point across numerous research fields.

    2024/07/19

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